More RU-486 now available for research

Mifepristone (RU 486) in Cushing's syndrome.

CONTEXT Mifepristone (RU 486) blocks the action of cortisol by binding to the glucocorticoid receptor and, therefore, is of potential therapeutic value in Cushing's syndrome. However, research in endogenous hypercortisolism has been hampered by the controversy related to the use of mifepristone for inducing abortion. Currently, new studies are planned to better define the role of RU 486 in Cush...

RU 486: the politics of choice.

Reversal of multidrug resistance by RU 486.

P-Glycoproteins represent a family of drug efflux proteins that convey multidrug resistance to cells in which they are expressed. This phenomenon can lower the efficacy of drugs used in chemotherapy. The steroid progesterone has been shown to bind P-glycoproteins and inhibit their drug efflux. We report that the antiprogestin RU 486 can reverse multidrug resistance in cells overexpressing the m...

Mifepristone (ru-486) and Its Analogues

Mifepristone (RU-486) is the first antiprogesterone drug used for the termination of early pregnancies (6 to 8 weeks pregnancies), a steroid synthesized in the laboratory. It has higher affinity for the progesterone receptor. It also has other potential applications as anticancer and glucocorticoid antagonist. It is desirable to increase its antiprogestational potency and eliminate the antigluc...

More Evidence-Based Internet Self-Help Depression Websites Now Available

The aim of this research study is to evaluate the availability and classification of the types of currently available Internet self-help websites for depression. Its aim is to develop an understanding of what is available for people at risk of depression who would otherwise perhaps not seek help and to investigate whether such useful resources are on the increase. In Australia, depression is th...